Five students of Teknobiomedik Science and Technology Faculty of Airlangga University Surabaya, East Java, managed to make artificial blood vessels (synthesis) biodegradable for cases of atherosclerosis. Five of these students are Iffa Aulia Fiqrianti, Claudia Yolanda Savira, Muhammad Abdul Manaf, Renata Bella Fitria, and Nadia Rifqi Cahyani.
Atherosclerosis is a thickening or narrowing of the arteries due to the buildup of plaque in the artery walls. This occurs when the cell layer on the inner wall of the artery, which is in charge of maintaining the smooth flow of blood, thickens and hardens to inhibit blood flow.
The findings of the five Unair students could be a much needed implant of atherosclerotic patients. Narrowing of blood vessels can lead to various fatal diseases, such as stroke, angina, and coronary heart disease.
Citing the Unair News page, Tuesday (1 // 8/2017), WHO reported, the disease of blood vessels and heart disease is not infectious with the highest mortality in the world, reaching 46 percent. In Indonesia, this disease causes 37 percent of deaths from total non-infectious disease deaths.
To treat atherosclerosis, vascular bypass surgery is usually performed using graft (live tissue grafted) blood vessels. Graft from donors or animals is also beginning to be abandoned because it can lead to rejection reactions from the patient’s body.
Another option is to use the graft from the patient’s own body. However this has a quality problem, because the patient has experienced vascular disease.
This condition makes patients need artificial graft (synthesis) is safe for the patient’s body, said Iffa Aulia Fiqrianti, chairman of the innovation team.
“We try to make blood vessels from poly L. lactic acid (PLLA), chitosan, and collagen.This PLLA is safe for the body, because it will decompose into lactic acid that can be absorbed by the body.The combination of chitosan and collagen can help cell attachment, so in the future When the graft decomposes and will be replaced by the patient’s own body cells, “said Iffa.
Previously there was already a commercial synthesis graft made of dacron. However, according to Iffa, the graft of the dacron is susceptible to calcification (hardening or calcification).
Iffa expects, the blood vessels synthesis of his team’s findings later can help improve the quality of life of patients vascular bypass surgery.
The clinical stage of the findings is long, but promising. The results of cytotoxicity test show that artificial blood vessels are not toxic, so it is safe to use in the body.
Previously, this study was prepared in a proposal entitled “Study In Vivo Vascular Graft Hollow Fiber PLLA Coating Chitosan-Collagen Cardiovascular Disease Solution Due to Atherosclerosis”. This proposal has passed Dikti and obtained research grant in PKM program Kemenristekdikti year 2016-2017.